Karla obtained her medical degree in 1987 in Brazil, and then completed a residency in psychiatry.  Between 1994 and 1997 she completed her PhD research in a programme supported jointly by the Universities of São Paulo (Brazil) and Oxford (England).  During that period she worked intensively with the Cochrane Collaboration, was involved with the activities of the Centre for Evidence-Based Medicine, and participated in a series of courses about methodological design and analysis of randomised trials, organised by the Centre.  In 1997 she was awarded her Doctorate, with merit.  After finishing her PhD she worked with the Brazilian Cochrane Centre (São Paulo, Brazil) and the Ibero-American Cochrane Centre (Barcelona, Spain), teaching and providing methodological support for reviewers.  At the end of 1998 she moved to Israel, and continued to work closely with the Cochrane Collaboration. Over the years, she has accumulated broad, hands-on experience relevant to the preparation of systematic reviews of both intervention studies and screening and diagnosis studies. Currently she is managing a small business company (www.enhance-reviews.com) that aims to outsource research work in evidence-based health care.